concept

SYNAPTIC PRUNING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPTIC PRUNING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

327Connections

4Hypotheses

5Analyses

50Outgoing

50Incoming

Summary

SYNAPTIC PRUNING is a concept in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with ALS, Aging, Als. Connected to 140 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SYNAPTIC PRUNING
Key Genes/Proteins	MICROGLIA, OVERVIEW, INFLAMMATION, COMPLEMENT, NEURODEGENERATIVE DISEASES, NEURON
Related Diseases	Neurodegeneration, Inflammation, Als, Alzheimer
Related Pathways	Complement, Phagocytosis
Linked Hypotheses	5 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SYNAPTIC_PRUNING["SYNAPTIC PRUNING"]
    SYNAPTIC_PRUNING -->|"activates"| neurodegeneration["neurodegeneration"]
    SYNAPTIC_PRUNING -->|"activates"| Alzheimer["Alzheimer"]
    SYNAPTIC_PRUNING -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SYNAPTIC_PRUNING -->|"activates"| Als["Als"]
    SYNAPTIC_PRUNING -->|"activates"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    SYNAPTIC_PRUNING -->|"activates"| Ms["Ms"]
    SYNAPTIC_PRUNING -->|"regulates"| Autism["Autism"]
    SYNAPTIC_PRUNING -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    complement_activation["complement activation"] -->|"activates"| SYNAPTIC_PRUNING
    microglia["microglia"] -->|"activates"| SYNAPTIC_PRUNING
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| SYNAPTIC_PRUNING
    MICROGLIA["MICROGLIA"] -->|"activates"| SYNAPTIC_PRUNING
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| SYNAPTIC_PRUNING
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| SYNAPTIC_PRUNING
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| SYNAPTIC_PRUNING
    P62["P62"] -->|"activates"| SYNAPTIC_PRUNING
    COMPLEMENT["COMPLEMENT"] -->|"inhibits"| SYNAPTIC_PRUNING

Outgoing (203)

Target	Relation	Type	Str
MICROGLIA	activates	gene	0.90
Neurodegeneration	activates	disease	0.75
Inflammation	regulates	disease	0.75
Als	implicated_in	disease	0.75
OVERVIEW	regulates	gene	0.70
MICROGLIA	regulates	gene	0.70
INFLAMMATION	regulates	gene	0.70
COMPLEMENT	implicated_in	gene	0.70
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.70
NEURON	implicated_in	gene	0.70
Complement	implicated_in	pathway	0.70
PHAGOCYTOSIS	activates	gene	0.70
Phagocytosis	activates	pathway	0.70
NEURON	activates	gene	0.70
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Epilepsy	associated_with	disease	0.65
Ms	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Autism	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Aging	regulates	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
ALS	regulates	disease	0.65
Depression	regulates	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	regulates	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Aging	associated_with	disease	0.65
Stroke	activates	disease	0.65
Infection	implicated_in	disease	0.65
Multiple Sclerosis	implicated_in	disease	0.65
Neurodegeneration	implicated_in	disease	0.65
Stroke	implicated_in	disease	0.65
Alzheimer	implicated_in	disease	0.65
Traumatic Brain Injury	implicated_in	disease	0.65
Autism	inhibits	disease	0.65
Als	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Als	contributes_to	disease	0.65
Alzheimer	contributes_to	disease	0.65

Incoming (124)

Source	Relation	Type	Str
MICROGLIA	associated_with	gene	0.90
NEURODEGENERATION	activates	gene	0.70
PYROPTOSIS	activates	gene	0.60
MICROGLIA	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
P62	activates	gene	0.60
COMPLEMENT	inhibits	gene	0.60
MICROGLIA	regulates	gene	0.60
TREM2	contributes_to	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
COMPLEMENT	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
C1Q	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
DEPRESSION	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
CYTOKINES	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
TREM2	therapeutic_target	gene	0.60
AUTOPHAGY	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
MITOPHAGY	implicated_in	gene	0.60
NEURODEGENERATION	implicated_in	gene	0.60
STROKE	activates	gene	0.60
AND	activates	gene	0.60
C1Q	activates	gene	0.60
SYNAPSE	activates	gene	0.60
AND	inhibits	gene	0.60
C1Q/C3	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
OVERVIEW	regulates	gene	0.60
AND	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
GENES	regulates	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
TSC2	inhibits	gene	0.60
ATG7	inhibits	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ASTROCYTE	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
SYNAPSE	associated_with	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between S	0.548	cell biology	What is the relative contribution of con
TREM2 Agonism to Redirect Microglia from Synaptic Pruning to	0.521	neurodegeneration	How do ALS-associated OPTN mutations mec
Synaptic Pruning Precision Therapy	0.465	Alzheimer's disease	Neuroinflammation and microglial priming
Complement-Mediated Synaptic Pruning Dysregulation	0.398	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (5)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Prolonged anesthesia induces neuroinflammation and complement-mediated microglia [PMID:36600274]	Xu F, Han L, Wang Y, Deng D, Ding Y, Zha	BMC Med	2023	2
Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024]	De Schepper S, Ge JZ, Sierksma A, Crowle	Nat Neurosci	2023	2
Young adult microglial deletion of C1q reduces engulfment of synapses and preven [PMID:41000995]	Petrisko TJ, Chu SH, Gomez-Arboledas A,	bioRxiv : the preprint server	2025	1
Gut-derived bacterial vesicles carrying lipopolysaccharide promote microglia-med [PMID:40731189]	Zhao X, Yu J, Xu B, Xu Z, Lei X, Han S,	Alzheimer's & dementia : the j	2025	1
Trigeminal neuralgia. [PMID:38816415]	Ashina S, Robertson CE, Srikiatkhachorn	Nature reviews. Disease primer	2024	1
Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455]	Cornell J, Salinas S, Huang HY, Zhou M	Neural Regen Res	2022	1
The Role of Complement in Synaptic Pruning and Neurodegeneration. [PMID:34595138]	Gomez-Arboledas A, Acharya MM, Tenner AJ	ImmunoTargets and therapy	2021	1
Early complement genes are associated with visual system degeneration in multipl [PMID:31289819]	Fitzgerald KC, Kim K, Smith MD, Aston SA	Brain	2019	1
Opioid Receptors. [PMID:26332001]	Stein C	Annual review of medicine	2016	1
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026	0
Sustained inhibitory dysfunction in complement component C1qa-deficient mice und [PMID:41544964]	Righes Marafiga J, Vu T, Bowlus J, Barab	Progress in neurobiology	2026	0
Synaptic pruning genes networks in Alzheimer's disease: correlations with neurop [PMID:40515808]	Sanfilippo C, Castrogiovanni P, Imbesi R	GeroScience	2026	0
Sex-Specific Molecular Architecture of Microglia-Mediated Neuronal Pruning Acros [PMID:41324815]	Sanfilippo C, Castrogiovanni P, Imbesi R	Molecular neurobiology	2025	0
Proteomic discoveries in hypermobile Ehlers-Danlos syndrome reveal insights into [PMID:40972649]	Griggs M, Daylor V, Petrucci T, Weintrau	ImmunoHorizons	2025	0
The dopamine analogue CA140 alleviates AD pathology, neuroinflammation, and resc [PMID:39129007]	Chae S, Lee HJ, Lee HE, Kim J, Jeong YJ,	Journal of neuroinflammation	2024	0
Single-cell RNA sequencing reveals distinct immunology profiles in human keloid. [PMID:35990663]	["Feng C", "Shan M", "Xia Y", "Zheng Z",	Frontiers in immunology	2022	0
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022	0
Adaptive learning algorithms to optimize mobile applications for behavioral heal [PMID:33657217]	Figueroa CA, Aguilera A, Chakraborty B,	Journal of the American Medica	2021	0
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021	0
A Novel N-terminal Region to Chromodomain in CHD7 is Required for the Efficient [PMID:34161779]	Lee E, Kang C, Purhonen P, Hebert H, Bou	Journal of molecular biology	2021	0

SYNAPTIC PRUNING

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Pathway Diagram

Outgoing (203)

Incoming (124)

Targeting Hypotheses (4)

Mentioning Analyses (5)

What determines the selectivity of complement-mediated synaptic elimination in p

Neuroinflammation and microglial priming in early Alzheimer's Disease